This thing you hu-mons call "KLEE-NUP" confuses and infuraties me!

I've discovered how useful photoshop is for doing the clean-rough stage for layouts. You can make a perspective guide by putting each vanishing point on its own layer and then drawing radiating lines from it. You drop the opacity of those layers to about 30% so you only see the lines faintly, then do your clean linework with the tablet. This is kind of like how John throws down a bunch of perspective lines and then picks out the building shapes from it.
The best part is that you can use as many points as you like without cluttering your page with lines: You just turn off all the guide layers except the one or two vanishing points you need at a time. Also, you can erase the lines from parts of the image that don't use them, such as when you do an overlay with its own set of points.
Clean up on the top layer, and you're Bob's nephew. Because you can turn off all your roughwork and perspective guides, you end up printing out something that's VERY easy to clean up over:

But because computer lines look like ass, cleanup still needs to be done in pencil. It's not often that I can hold back the caffeine jitters long enough to clean up a whole page, but it eventually happened: